Epithelial injury induces an innate repair mechanism linked to cellular senescence and fibrosis involving insulin-like growth factor binding protein -5
نویسندگان
چکیده
Page 1 of 26 Accepted Preprint first posted on 1 August 2008 as Manuscript JOE-08-0269 Copyright © 2008 by the Society for Endocrinology.
منابع مشابه
IGFBP-5 induces epithelial and fibroblast responses consistent with the fibrotic response.
Fibrosis involves activation of fibroblasts, increased production of collagen and fibronectin and transdifferentiation into contractile myofibroblasts. The process resembles aspects of wound-healing but remains unresolved and can be life-threatening when manifest in the kidneys, lungs and liver, in particular. The causes are largely unknown, but recent suggestions that repetitive micro-injury r...
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